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Hereditary diseases of cats

CSD009
Progressive Retinal Atrophy rdAc
PRA rdAc
5
Cats
Retinal degeneration II
Some breeds
  • Big indian kalao
  • Great munsterlander
  • Greater swiss mountain dog
  • Big elo
  • Bombay cat
  • Border Collie
  • Dogue de bordeaux
  • Greyhound
  • Bearded collie
  • Beauceron
  • Boston terrier
  • Brazilian terrier
  • Breton epagnol
  • Briard
  • Waller

Hereditary diseases
Progressive retinal atrophy is the general name for a group of retinal diseases that cause damage to photoreceptor cells - rods and cones - up to their death. Currently, a hereditary form of late receptor degeneration called rdAc has been described for some cat breeds. This disease has an autosomal recessive nature of inheritance and is detected by a DNA test showing the presence and number of abnormal copies of the gene, which allows you to identify sick and healthy cats, as well as to identify healthy carriers. Carriers have PRA rdAc in a latent form and can transmit the disease to their offspring, being healthy themselves. At birth, affected kittens have normal vision, but at the age of one and a half to two years, with an ophthalmological examination, a change in the fundus becomes noticeable. Electroretinography (ERG) allows detecting the first signs of the disease from the age of seven months - a significant change in the EGR amplitudes. Morphological abnormalities of individual photoreceptors are observed from five to eight months of age. The rods are the first to degenerate, then the cones. Complete degeneration of receptors, leading to blindness of the animal, occurs, as a rule, by three to seven years (depending on the individual characteristics of the cat).
Autosomal recessive inheritance
CEP290
N
M