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Dog hereditary diseases

DCD002
Chondrodysplasia (CDPA) and chondrodystrophy with risk of degeneration of the intervertebral discs
CDDY, IVDD
5
Dogs
CDPA and CDDY
Hereditary diseases

Description
Chondrodysplasia (CDPA) is a pathology associated with deformity, abnormal shape and long limbs, caused by a violation of the formation of cartilage tissue. It is the norm for a number of breeds.

Chondrodystrophy (CDDY) with risk of intervertebral disc degeneration (IVDD) has a similar phenotype but is associated with progressive structural changes in the intervertebral disc. Affected dogs may experience premature calcification of a portion of the disc at an early age (from birth to 1 year of age), leading to disc degeneration at a young age and consequences such as hernia, inflammation and hemorrhage, causing severe pain and neurological dysfunction. Chondrodystrophy (CDDY) is inherited as a semi-dominant trait, which means that dogs with two copies of the mutant gene are smaller than those with one. Degeneration of intervertebral discs is inherited in a dominant manner - one copy of the mutant gene with CDDY is enough to manifest the disease. The presence of a mutation does not always lead to disc degeneration. Brown et al. 2017 showed an association of chondrodystrophy with an IVDD risk of about 34%. Intervertebral disc problems can be caused by other causes. Simultaneous testing for CDPA and CDDY allows you to identify a negative mutation and conduct selection against it, minimizing the risk of disc degeneration.

Symptoms
Intervertebral disc disease (IVDD) can cause a variety of symptoms in dogs, ranging from mild pain, partial paralysis to complete paralysis. In most cases, something in between occurs, chromate on the hind or front limb, when turning, the animal falls on its side, the abdominal cavity is tense and very painful. Also, among the signs of the disease there are: neck pain (unwillingness to move the neck or head), head down, back pain and stiffness, the animal is hunched over, urinary retention, urinary impairment, lack of coordination, ataxia, fear, muscle tremor, paralysis one or more limbs.

Diagnostics
Characteristic changes in the behavior and physiology of the dog.

FGF4
  • Affenpinscher
  • Afghan Hound
  • Airedale
  • Akita
  • Alaskan Klee-Kai
  • Alaskan malamute
  • American akita
  • American bulldog
  • American bully
  • American cocker spaniel
  • American eskimo
  • American foxhound
  • American hairless terrier
  • American pit bull terrier
  • American staffordshire terrier
  • American water spaniel
  • Appenzeller mountain dog
  • Australian cattle dog
  • Australian cobberdog
  • Australian herding dog
  • Australian kelpie
  • Australian labradoodle
  • Australian shepherd
  • Australian short-tailed herding dog
  • Australian silky terrier
  • Australian terrier
  • Barbet
  • Basenji
  • Basset griffon vendee
  • Basset hound
  • Beagle
  • Bearded collie
  • Bearded collie
  • Beauceron
  • Beaver
  • Bedlington terrier
  • Belgian griffon
  • Belgian shepherd
  • Belgian shepherd Malinois
  • Belgian shepherd Tervuren
  • Bergam shepherd
  • Bernedoodle
  • Bernese mountain dog
  • Bichon frize
  • Big elo
  • Big poodle
  • Black russian terrier
  • Boerboel
  • Bolognese
  • Border Collie
  • Boston terrier
  • Boxer
  • Boykin spaniel
  • Brazilian terrier
  • Breton epagnol
  • Briard
  • Brussels griffon
  • Bull terrier standard
  • Bulldog
  • Bullmastiff
  • Bully Kutta
  • Cairn terrier
  • Canary dog
  • Cane corso
  • Catahula Leopard dog
  • Caucasian shepherd dog
  • Cavalier king charles spaniel
  • Central asian shepherd dog
  • Chesapeake bay retriever
  • Chihuahua
  • Chinese crested dog
  • Chinese fu dog
  • Chow Chow
  • Clumber spaniel
  • Cockapoo
  • Collie rough
  • Collie shorthair
  • Collie smooth-haired
  • Coton de Toualer
  • Cromforlander
  • Curly coated retriever
  • Czechoslovakian wolfdog
  • Dachshund miniature long-haired
  • Dachshund miniature smooth-haired
  • Dachshund miniature wire-haired
  • Dachshund rabbit long-haired
  • Dachshund rabbit smooth-haired
  • Dachshund rabbit wire-haired
  • Dachshund standard
  • Dachshund standard long-haired
  • Dachshund standard wire-haired
  • Dalmatian
  • Dandy dinmont terrier
  • Danish swedish farmdog
  • Deerhound
  • Doberman
  • Dogue de bordeaux
  • Drent partridge dog
  • Dutch shepherd
  • Dutch tulphond (Marchisier)
  • Dwarf poodle
  • East european shepherd
  • East Siberian Laika
  • English bulldog
  • English cocker spaniel
  • English mastiff
  • English pointer
  • English Setter (Llewellyn)
  • English shepherd
  • English springer spaniel
  • English toy terrier
  • Entlebucher mountain dog
  • Field spaniel
  • Finnish hound
  • Finnish lapphund
  • Flanders bouvier
  • Flatcoated retriever
  • Fox terrier
  • Fox terrier smooth
  • Fox terrier wire-haired
  • French bulldog
  • French spaniel
  • German boxer
  • German dog
  • German drahthaar
  • German langhaar
  • German pinscher
  • German shepherd
  • German shepherd longhaired
  • German shorthaired pointer
  • German spitz big
  • German spitz medium
  • German spitz miniature (small)
  • German spitz toy (Pomeranian)
  • German wachtelhund
  • German Wolfspitz (Keeshond)
  • Giant schnauzer
  • Golden retriever
  • Goldendoodle
  • Great munsterlander
  • Greater swiss mountain dog
  • Greyhound
  • Greyhound
  • Harlequin miniature
  • Harlequin toy
  • Havana Bichon
  • Hokkaido
  • Hovawart
  • Hungarian vizsla
  • Irish red and white setter
  • Irish red setter
  • Irish soft coated wheaten terrier
  • Irish Terrier
  • Irish water spaniel
  • Irish wolfhound
  • Italian Cane Corso
  • Italian greyhound
  • Italian spitz
  • Jack Russell Terrier
  • Jagd terrier
  • Jamthund (Swedish laika)
  • Japanese chin
  • Japanese spitz
  • Karelian bear dog
  • Kawapoo
  • Keeshond
  • Kerry blue terrier
  • King charles spaniel
  • Koikerhondje
  • Kuvasz
  • Labrador retriever
  • Labrooodle original
  • Lagotto romagnolo (Italian water dog)
  • Lakeland terrier
  • Lancashire healer
  • Landseer
  • Lapland reindeer dog
  • Leonberger
  • Lhasa apso
  • Lucas Terrier
  • Maltese
  • Maltipoo
  • Manchester terrier
  • Mastiff
  • Metis
  • Mexican hairless dog
  • Miniature american shepherd
  • Miniature australian shepherd
  • Miniature bull terrier
  • Miniature Pinscher
  • Miniature pinscher
  • Miniature poodle
  • Miniature schnauzer
  • Mittel schnauzer
  • Moody
  • Moscow watchdog
  • Neapolitan mastiff
  • Newfoundland
  • Norfolk terrier
  • Norwegian elkhund
  • Norwich terrier
  • Old Danish Pointer (Pointing Dog)
  • Old english bulldog
  • Old English Shepherd Dog (Bobtail)
  • Papillon
  • Parson russell terrier
  • Patterdale terrier
  • Pekingese
  • Petersburg orchid
  • Petit Brabancon
  • Phalen
  • Phantom miniature
  • Pharaoh hound
  • Polish lowland shepherd
  • Polish podgalyanska shepherd
  • Portuguese podengu (Portuguese rabbit dog)
  • Portuguese water dog
  • Prague ratter
  • Priter
  • Pug
  • Puli
  • Pumi
  • Pyrenean mountain dog
  • Rat terrier
  • Redhead Breton Basset
  • Rhodesian ridgeback
  • Rottweiler
  • Russian colored lapdog
  • Russian hunting greyhound
  • Russian toy
  • Russian-european laika
  • Saarloos Wolfdog
  • Saluki
  • Samoyed dog
  • Schipperke
  • Scotch terrier
  • Scottish retriever
  • Scottish setter (Gordon setter)
  • Scottish terrier
  • Sealyham terrier
  • Setter Gordon
  • Shar pei
  • Sheltie
  • Shiba inu
  • Shih tzu
  • Shorty bull
  • Siberian husky
  • Silky windhund
  • Sky terrier
  • Slugs
  • Small brabancon
  • Small elo
  • Small lion dog
  • Small munsterlander
  • Small poodle
  • Spanish water dog
  • Spinone Italiano
  • St. Bernard
  • Stabihun
  • Staffordshire bull terrier
  • Standard poodle
  • Straight-haired retriever
  • Sussex
  • Sussex spaniel
  • Swedish lapphund
  • Swedish walhund
  • Teddy roosevelt terrier
  • Tenterfield terrier
  • Thai ridgeback
  • Tibetan mastiff
  • Tibetan spaniel
  • Tibetan terrier
  • Toy fox terrier
  • Toy poodle
  • Toy poodle
  • Turkmen alabay
  • Volpino italiano
  • Walking dog
  • Waller
  • Weimaraner
  • Weller
  • Welsh Corgi Cardigan
  • Welsh Corgi Pembroke
  • Welsh springer spaniel
  • Welsh terrier
  • West highland white terrier
  • West siberian laika
  • Westphalian Terrier
  • Whippet
  • Whippet longhaired
  • White swiss shepherd
  • Yakut laika
  • Yorkshire Terrier

Individual breeds