Dog hereditary diseases

Description
An inherited disease in dogs caused by a disruption in the transport of the amino acid cystine. Normally, cystine is reabsorbed in the kidneys and does not pass into the urine. However, in dogs with cystinuria, the transport protein responsible for renal absorption of cystine is impaired. This leads to the fact that in acidic urine, cystine begins to form crystals, and then cystine "stones" in the kidneys and / or bladder. The formation of "stones" creates the preconditions for the formation of a complex set of disorders, including blockage of the urinary tract and the development of a serious bacterial infection. Since the urinary tract in males is much narrower than in females, the disease in males is more severe. In this case, stretching and / or rupture of the bladder, kidney failure, may occur; possible death.

Dogs of many breeds suffer from cystinuria. In dogs, cystinuria develops at an average age of 4.8 years, while in Newfoundlands - at the earliest stages: already at the age of 6 months - one year. Although the incidence of cystinuria is not the highest in Newfoundlands, it is believed that cystine crystal formation in this breed has an increased health risk and is more severe.

Diagnostics
Since the disease is of a genetic nature, a DNA test has been developed for diagnosing sick dogs, as well as genetic carriage, available for Newfoundland dogs. The advantage of genetic testing is the ability to identify dogs that do not show signs of the disease, but are carriers (heterozygotes), which means they can transmit the defect to their offspring.

DNA test is based on the use of the latest molecular genetic knowledge and technology. It allows with 100% certainty to distinguish a healthy dog ​​from clinically normal dogs that are carriers and from sick dogs, including those in which symptoms of disorders have not yet appeared. Testing can be done at any age, for both puppies and adult dogs.