Dog hereditary diseases

DSD085
Spongy cerebellar degeneration with cerebellar ataxia
SDCA1
10
24
Dogs
Hereditary diseases

Description
Spongy cerebellar degeneration with cerebellar ataxia type 1 (SDCA1) is a neurodegenerative disease.

The disease is caused by a mutation in the KCNJ10 gene, which encodes potassium channels present in the central nervous system, eyes, inner ear and kidneys (Van Poucke et al., 2017). The functioning of the channels changes due to the mutation, reducing the membrane potential, and, subsequently, neurological seizures develop.

According to some reports, the incidence of the mutant allele in the Malinois population is about 2.9%.

Symptoms
Symptoms develop between the 4th and 9th weeks. Affected animals exhibit a characteristic gait with widely spaced hind legs, which helps them to maintain stability and improve coordination of movements. Signs such as tremors, stumbling, loss of stability, jumping, and falling may also occur. Some dogs develop muscle spasms caused by stressful situations or exercise.

Diagnostics
Characteristic changes in the behavior and physiology of the dog.

  • Autosomal recessive inheritance

    AR
    MM - sick
    NM - healthy, carrier
    NN is healthy
KCNJ10
  • Belgian shepherd
  • Belgian shepherd Malinois
  • Belgian shepherd Tervuren

Individual breeds