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Dog hereditary diseases

DSD024
Muscular dystrophy of the cavalier king charles spaniels
DMD
5
Dogs
Hereditary diseases

Description
The disease is analogous to Duchenne muscular dystrophy in humans and is associated with a lack of the protein dystrophin, which is responsible for the normal functioning of the muscular system. It is characterized by progressive weakness and muscle atrophy, which ultimately leads to the death of the animal. Clinical signs appear in puppies at 8-10 weeks, initially in the form of weakness in the limbs, shuffling and shortened stride, inability to fully open the jaw, difficulty eating, thickening of the base of the tongue, excessive salivation. Posture is impaired, back deflection increases, weakness and trembling of the joints are observed. From the first weeks of life, there is an accumulation of intracellular calcium, increased serum concentrations of creatine kinase (up to 300 times normal). Gradually, the degeneration of muscle fibers progresses, necrosis develops (partially muscle fibers can regenerate), mineralization and fatty infiltration of both skeletal and cardiac muscles are noted. The lesions of the heart muscle may be less severe and usually develop in the ventricles after 6 months of age. Carrier (NM) bitches usually do not show signs of illness, but in some cases partial muscular system disorders (weakness, elevated creatine kinase levels, changes on electromyography) may be noted.

Symptoms

Diagnostics
Characteristic changes in the behavior and physiology of the dog.

DMD
Cavalier king charles spaniel
Individual breeds