ATTENTION!

For the duration of the hostilities, the work of the Representative Office in Ukraine is temporarily suspended!
ZOOGEN is out of politics, we sincerely sympathize with everyone unwittingly drawn into the conflict and wish it a speedy end! Peace to all!

If you cannot contact the Representative Office in Ukraine - call our phones, write to e-mail and social networks! We will definitely answer and help you!

Under any circumstances, the ZOOGEN Company confirms its obligations to carry out studies, as well as for the prepaid coupons sold, regardless of the political situation.

Dog hereditary diseases

DSD035
Primary lens dislocation
PLL
5
Dogs
Lens luxation
Hereditary diseases

Description
Primary Lens Luxation (PLL) is a hereditary disease that is the displacement of the lens of the eye from the vitreous fossa (bed of the lens). Normally, the lens is held in place by the ciliary girdle - a system of fibers extending from the ciliary processes to the lens capsule and attaching to the area of ​​its equator. With PLL, abnormalities of the girdle fibers occur, as a result of which the lens is no longer fixed and can freely move between the anterior and posterior chambers of the eye through the opening of the pupil.

A dog with PLL may experience pain. Displacement of the lens to the cornea can lead to impaired fluid circulation, increased eye pressure and, as a result, glaucoma, damage to the optic nerve and retina. If untreated, the animal goes blind. Lens displacement can also be caused by trauma or certain pathologies that lead to changes in the normal anatomy of the eye, such as glaucoma or intraocular tumors. In this case, we can talk about a non-hereditary form of the disease, but often injuries are a secondary cause and cause rupture of ciliary fibers already weakened as a result of PLL. PLL occurs in a variety of breeds. This disease is most common in terriers and related breeds. As a rule, the disease cannot be detected until one of the lenses is strongly displaced from the vitreous pit. This pathology is bilateral, and the luxation of the second lens usually occurs a week or a month after the first. At the level of ultrasound analysis, an anomaly of the girdle fibers can be observed already from 20 months, long before the actual displacement, which manifests itself at the age of 3 to 8 years (on average, 4-5 years).

Diagnostics
Characteristic changes in the behavior and physiology of the dog.

  • Autosomal recessive inheritance

    AR
    MM - sick
    NM - healthy, carrier
    NN is healthy
ADAMTS17
  • Puli
  • Pumi
  • Rat terrier
  • Russian toy
  • American eskimo
  • American hairless terrier
  • Australian cattle dog
  • Australian kelpie
  • Australian short-tailed herding dog
  • Beaver
  • Bedlington terrier
  • Border Collie
  • Breton epagnol
  • Chinese crested dog
  • Chinese fu dog
  • Danish swedish farmdog
  • Fox terrier
  • Fox terrier smooth
  • Fox terrier wire-haired
  • German wachtelhund
  • Jack Russell Terrier
  • Jagd terrier
  • Lakeland terrier
  • Lancashire healer
  • Lucas Terrier
  • Manchester terrier
  • Miniature bull terrier
  • Norfolk terrier
  • Norwich terrier
  • Parson russell terrier
  • Patterdale terrier
  • Pug
  • Sealyham terrier
  • Teddy roosevelt terrier
  • Tenterfield terrier
  • Tibetan terrier
  • Toy fox terrier
  • Volpino italiano
  • Welsh terrier
  • West highland white terrier
  • Westphalian Terrier
  • Yorkshire Terrier

Individual breeds