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Goat genetics

GSC002
Mucopolysaccharidosis IIID, G6-Sulfatase Deficiency
G6-S MPSIIID
10
23
Nubian and related breeds
N - normal allele of the gene
G - mutant allele of the gene
The disease is transmitted in an autosomal recessive manner. An inherited metabolic defect that occurs in Nubian goats and related breeds. A mutation in the GNS gene leads to a breakdown in the breakdown of complex polysaccharides known as heparin sulfate glycosaminoglycans (HS-GAG), as a result of which they accumulate in the tissues of the central nervous system and internal organs. In goats suffering from G6-sulfatase deficiency, there is a delay in the development of motor activity, growth retardation. The disease leads to early death.
GNS